THBS2 and infection: Although infection of hamsters with Ov-tsp-2 dsRNA-treated parasites was not investigated in this earlier report, the damage to the tegument following exposure to Ov-tsp-2 dsRNA in worms cultured for several days appeared to be so extensive and debilitating that worms damaged to that extent by either CRISPR-based genome knockout or dsRNA likely could not establish or survive for long periods in vivo.