CTLA4 and cancer: Cancers with high tumor-infiltrating lymphocytes (e.g., lung cancers) had high expression of immune-oncology markers, such as PD-L1, TIM3, FOXP3, PD-1, CTLA4, and LAG3 in TMA EdgeSeq and TCGA RNA-seq; this was also observed in normal hematopoietic tissues with TMA EdgeSeq (Fig 1B).