We observed modest induction of IFNB1 following infection of differentiated preadipocytes, but did not observe induction of IFNA1, ISG15, IFI27, or IER3. Thus, SARS-CoV-2 infection of adipose tissue induces antiviral responses that change over time, and these responses are muted in adipocytes compared to SVC. Here, IFNA1 is linked to infection.