PKM and breast cancer: In fact, gLINC lnc-RNA was recently reported to act as a backbone for complex formation between PGK1/ENO1/ and PKM2, along with LDHA, promoting glycolytic flux and ATP production [35]; in the same way NEAT1 lncRNA forms a scaffold bridge for the assembly of the glycolytic complex PGK1, PGAM and ENO1 promoting a glycolytic state in breast cancer that is associated with more invasive and higher-grade tumors [36].