In fact, if the absence of nucleolar expression was regularly observed, in similar proportions between low- and high-grades, in both B and T nodal lymphoma cells, a significant increase in cytoplasmic netrin-1 expression in high-grade, compared with low-grade, was present in B-cell nodal lymphomas (the increase in high-grade T-cell lymphomas was not significant). This evidence concerns the gene NTN1 and T-cell non-Hodgkin lymphoma.