This gain of netrin activity was proven to be a selective advantage for tumor cells survival, as downregulation of netrin-1 expression with siRNAs or interference in netrin-1 binding to its receptors via use of decoy recombinant peptides are associated with tumor cell death, both in vitro and in vivo [16,38,39,40,43]. The gene discussed is NTN1; the disease is neoplasm.