IFNL3 and chronic hepatitis C virus infection: Therefore, this real-life case-control retrospective study aimed to evaluate the genotype and allele frequency distributions of IL28B (rs12979860) in Egyptian patients with chronic hepatitis C disease who obtained SOF/DCV ± ribavirin (RBV) and assess IL28B polymorphisms as predictors of SVR to SOF based therapy for HCV in Egyptian patients, which is essential to provide more practical information for better management of chronic hepatitis C patients.