A decreased frequency of FOXP3+ Tregs has been observed in the peripheral blood of some, but not all, STAT3 GOF patients, and taken together with the overlapping clinical features in STAT3 GOF and IPEX syndrome, it has been suggested that this disease falls within the spectrum of Tregopathies (10, 14). The gene discussed is STAT3; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.