The ratio of Ly5.1+/Ly5.1– cells recovered in the MLN of treated mice was significantly higher in mice treated with STAT3 GOF Tregs compared with those treated with WT Tregs (14.9 versus 3.6, respectively), suggesting that local control of colitis cell accumulation may be impaired in these mice (Figure 6D). Here, STAT3 is linked to colitis.