Further transcriptome analysis revealed overexpression of ERG and BMP2, downstream genes previously shown to be strongly upregulated in C/G AML (2, 13), and decreased expression of the erythroid-megakaryocyte differentiation gene GATA1 (24–28), downregulated in C/G AML (13), in both EC coculture and MC (Figure 3B). Here, GATA1 is linked to acute myeloid leukemia.