We examined whether response rates of SARS-CoV-2–specific antibodies (IgG1, IgG3, total IgG, and IgA) differed between PLWH and PWOH participants after adjusting for peak COVID-19 symptom severity, demographics, preexisting medical conditions, smoking history, region, and days since SARS-CoV-2 diagnosis. Here, CD79A is linked to COVID-19.