Tholey et al. [25] have both used the degradable C32 polymer or Lipofectamine 2000 to demonstrate that Mucin1 (MUC1), found overexpressed in pancreatic ductal adenocarcinoma (PDA) and being associated to tumor aggressiveness, could be targeted by transfection with a single dose of MUC1 promoter-driven DT-A. The gene discussed is MUC1; the disease is neoplasm.