When exposed to alcohol, a zebrafish mutant with histone H4 transcription factor (hinf), polo-like kinase 1 (plk1), forkhead box 1 (foxi1) and methionyl-tRNA synthetase (mars) knockout shows a smaller ventral viscerocranium, microcephaly and microphthalmia [65]. The gene discussed is MARS1; the disease is microcephaly.