In vitro studies of granule neurons from the cerebellums of mice showed that MeHg exposure impaired cofilin phosphorylation balance [66], while the study of Shao et al. [67] compared the different response patterns of astrocytes and cerebellar granule neurons upon MeHg exposure and showed the regulation of the cytoskeleton, mitochondria components, and even Huntington’s disease features based on KEGG pathway enrichment analysis. Here, CFL1 is linked to Huntington disease.