Similarly, RP105 showed significant negative correlation with expression of ACTA (ASMA) in fibroblasts from patients with SSc at both mRNA (r = –0.53, P = 0.035; Pearson’s correlation) (Figure 1B) and protein (r = –0.66, P = 0.034; Pearson’s correlation) levels (Figure 1C). This evidence concerns the gene ACTA1 and systemic sclerosis.