Aside from chronic inflammation,5 hyperglycemia alone is known to be associated with superficial punctate keratopathy, trophic ulcers, persistent epithelial defects, recurrent corneal erosions, and lower values of tear secretion and tear film break-up time, which may cause DED in patients with T2D.5 In this study, we evaluated HbA1c levels during the follow-up periods to explore possible mechanisms of DED with SGLT2 inhibitors. This evidence concerns the gene SLC5A2 and Hyperglycemia.