TARDBP and amyotrophic lateral sclerosis: Indeed, the pivotal role of protein-RNA interactions in aggregation is becoming increasingly clear: while for some mutations of ALS-related genes, such as TARDBP, FUS, HNRNPA2B1 and HNRNPA1, the purified mutated proteins alone were often sufficient to enhance its aggregation propensity [20, 40–42], recent studies demonstrated the RNA ability to hinder or promote aggregation [63, 64, 76].