The medications used to treat patients with obesity and T2DM include glucagon-like peptide 1 receptor agonists (GLP1-RAs) and sodium-glucose co-transporter 2 inhibitors (SGLT2is), both of which have additional clinical benefits beyond improving glucose homeostasis and promoting weight loss [19]. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.