Cactus, in a non-signaling condition, is attached to the Dif and/or Dorsal and prevents nuclear localization and their activity, so Cactus degradation is needed for nuclear transaction for Dif/di. Upon the infection and signal induction, Cactus degradation occurs and causes the translocation of Dif/di to the nucleus, which activates the expression of antimicrobial peptides [79]. The gene discussed is TNF; the disease is infection.