The integrated optical density (IOD)/area of the KLF5 protein in the HF.M group (72.45 ± 7.02 versus 121.52 ± 10.19; P = 0.002) and RDN group (79.34 ± 22.17 versus 121.52 ± 10.19; P = 0.040) was lower than that in the HF group (Fig. 1A and C). The gene discussed is KLF5; the disease is hydrops fetalis.