In addition, it has been reported that renal denervation (RDN), which downregulates sympathetic nerve activities by ablating renal sympathetic nerves, significantly suppresses renal induction of KLF5 in mice undergoing transverse aortic constriction (TAC) (12), showing that KLF5 levels may be influenced by RDN. This evidence concerns the gene KLF5 and persistent truncus arteriosus.