Sutterella was increased in patients with coronary heart disease and associated with obesity (29) and diabetes (30), and it could also impair the function of the intestinal antibacterial immune response (31) by regulating the levels of interleukin-13 transcripts (32), which is an important relevant cytokine that is known to affect epithelial barrier integrity (31). The gene discussed is IL13; the disease is obesity due to melanocortin 4 receptor deficiency.