KLF5 and hydrops fetalis: Although RDN suppressed renal KLF5 expression, it is unclear whether intestinal expression of KLF5 can also be affected by RDN in HF and whether inhibiting intestinal KLF5 expression exacerbates the gut microbiome and weakens the role of RDN in mitigating gut microbiome aberrations in HF rats after RDN.