Western blot analysis also showed that the relative expression of KLF5 protein in the HF.M group (0.91 ± 0.23 versus 1.87 ± 0.39; P < 0.001) and RDN group (1.18 ± 0.24 versus 1.87 ± 0.39; P = 0.004) was decreased compared with that in the HF group. The gene discussed is KLF5; the disease is hydrops fetalis.