For instance, in mesenchymal TNBC and malignant rhabdoid tumors, which arise in the brain, kidney, and other soft tissues, the loss of SNF5 (INI1) results in the altered genomic deposition of the PRC2 complex in H3K27me3 residues, leading to the repression of lineage-specific target genes [122]. Here, SMARCB1 is linked to rhabdoid tumor.