In this scenario, EZH2 plays a key role in tumoral development, and the different disease states can be classified as amphicrine PCa (AMPC), which expresses AR but has a decreased canonical AR signaling pathway and more NE features, double-negative PCa (DNPC) that does not express AR or neuronal markers, terminal neuroendocrine PCa (NEPC) that expresses neural markers, and squamous cell carcinoma that turns on the basal cell markers, such as Krt5 or p63 [180,181] (Figure 3). Here, AR is linked to squamous cell carcinoma.