In addition, the epigenomic profiling of histone modifications (H3K27ac, H3K4me3 and H3K27me3) in human NEPC and selected LuCaP PCa patient-derived xenografts showed a significant reprogramming of the master transcriptional regulator Forkhead box 1 (FOXA1) and an increase in H3K27ac at the FOXA1 binding site, related to the promotion of neuroendocrine lineage-defining genes [191]. This evidence concerns the gene FOXA1 and posterior cortical atrophy.