EZH2 and small cell lung carcinoma: In this context, a recent functional genomics screen in K562 leukemia cells [209] and studies in SCLC and TNBC [210,211] showed that EZH2 inhibition modulates the IFN-γ response, leading to MHC-I upregulation, and this effect is mediated by H3K27me3 repressive marks [206,210].