CDKN2A and T-cell non-Hodgkin lymphoma: In B and T-cell lymphomas, it has been shown that BMI1 (a subunit of PRC1, which promotes self-renewal in skeletal muscle [149]) acts as a proto-oncogene inhibiting Myc-induced apoptosis through repression of the cyclin-dependent kinase inhibitor 2A (Cdkn2a), the gene responsible for the expression of INK4 and ARF proteins, which restrict cellular proliferation [150].