Consistently, our previous studies indicated that EZH2 inhibition in PCa models activates a double-stranded RNA–STING–IFN stimulated genes (ISG) stress response that results in the upregulation of genes involved in antigen presentation, Th1 chemokine signaling and interferon response, including PD-L1, which is dependent on STING activation [208] (Figure 4A). Here, EZH2 is linked to posterior cortical atrophy.