Moreover, in different cancer types, including melanoma [216] and ovarian [217], and in PCa mouse models [208], it has been shown that EZH2 inhibition leads to an increase in the intra-tumoral trafficking of activated CD8+ T-cells, and this recruitment is mediated by CXCL10-CXC chemokine receptor 3 (CXCR3) [203,218,219,220]. This evidence concerns the gene EZH2 and melanoma.