Interestingly, EZH2, BMI1 and the histone demethylase (HDM) Lysine Demethylase 6B (KDM6B also called JMJD3), which can remove H3K27me3, have been associated with EMT, poor prognosis and metastasis in cancer [93,198,199,200]. Here, EZH2 is linked to cancer.