More recently, Shields et al. demonstrated that the depletion of BMI1, which is implicated in the transformation of normal human myoblasts into alveolar rhabdomyosarcoma (ARMS), delays tumor growth via activation of the Hippo pathway by LATS1/2 phosphorylation, leading to reduction in YAP levels and YAP/TAZ target genes [153,154]. Here, LATS1 is linked to alveolar rhabdomyosarcoma.