Our recent report [85] demonstrated a minimally invasive closed-chest MI-swine model, which simulated the clinical MI and displayed decreased ejection fraction compared, abnormal ECG patterns reflecting the myocardial ischemia and infarction, increased levels of biomarkers including Troponin I, LDH and CCK than the baseline control and histological alterations, including ECM disorganization, hypertrophy, inflammation, and angiogenesis confirming the MI [85]. The gene discussed is CCK; the disease is myocardial infarction.