Wu et al. [78] demonstrated that the temperature-sensitive aliphatic polyester hydrogel PVL-b-PEG-b-PVL conjugated with vascular endothelial growth factor (VEGF), attenuated adverse cardiac remodeling, preserved scar thickness, and improved ventricular function, and increased blood vessel density as compared to the hydrogel or VEGF alone using MI-rat model. Here, VEGFA is linked to myocardial infarction.