The NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells), Bcl-2, p53, TNF-related apoptosis-inducing ligand (TRAIL), ubiquitin ligases, overexpression of COX-2, mitogen-activated protein kinase (MAPK/ERK) pathways have significant role in skin cancers. This evidence concerns the gene TP53 and skin neoplasm.