The interleukin-15 (IL-15)- and cisplatin (CDDP)-loaded poly (ethylene glycol)-poly(γ-ethyl-L-glutamate) diblock copolymers (mPEG-b-PELG) thermosensitive hydrogels injected into mice bearing B16F0-RFP melanoma cells exhibited synergistic immune regulations such as Cyclin A2, CDK2 and Cdc25A expression was significantly reduced [143]. This evidence concerns the gene IL15 and melanoma.