Both B7-H3 and B7-H4 are over-expressed in several solid and hematologic malignancies, and their expression is associated with poor prognosis in many cancers, including renal cell carcinoma (RCC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC) [75,76,77]. This evidence concerns the gene VTCN1 and non-small cell lung carcinoma.