The expressions of the most prominent signature genes of tumor-infiltrating Tregs, such as CXCR5, IL17F, IL17A, IL22, FOXP3, IL12RB2, TNFRSF9, CD274, TNFRSF4, TNFRSF9, IL10, CCR7 and STAT1, were also investigated (Figure 5A). The gene discussed is IL22; the disease is neoplasm.