Treg signature genes CXCR5, TNFRSF9, CCR7, STAT1, GBP4, and EOMES were significantly upregulated in the young cohort and were correlated with higher survival in melanoma (Figure 5B–H), while ID3, IL-17A, IL-17F, RDH10 and IL-11 were significantly upregulated in the old cohort (Figure 5A). The gene discussed is CXCR5; the disease is melanoma.