Animal experiments have shown that the melanoma cell line Yumm1.7 derived from a BrafV600E/Cdkn2a−/−/Pten−/− mouse model of melanoma grows slowly but aggressively in aged mice with increased angiogenesis and metastases due to the age-related increase in the Wnt antagonist sFRP2 [9]. This evidence concerns the gene CDKN2A and melanoma.