Cortical astrogliosis was observed in the LateSepsis animals (4.84 ± 3.10 %) compared with WT-Sepsis animals (6.80 ± 2.16%, p = 0.0028), EarlySepsis animals (1.94 ± 1.11%, p = 0.0032), APP-Sham animals (2.77 ± 0.47%, p = 0.048) (Figure 4e). This evidence concerns the gene APP and Sepsis.