By applying the CLP sepsis model to APP/PS1 (a transgenic mouse model of AD in which Aβ can be detected as early as 6 weeks of age in the cortex and at 8 weeks of age in the hippocampus [42]) we were able to simulate a sepsis episode before (EarlySepsis group) and after (LateSepsis group) the start of Aβ deposits in the CNS of the animals. The gene discussed is APP; the disease is Alzheimer disease.