Mutations were identified in Exon 8 Hsp D in four cases and Exon 7 Hsp D in two cases, with one of these having mutations in both; Exon 6 in another four cases and one case each with mutations in Exon 5 Hsp A and Exon 5 Hsp B. The samples with hyperkeratosis (HK) had a low rate of positive TP53-protein staining (13%) and mutations (three out of twenty tested, in Exon 5 Hsp A (two cases) and Exon 8 Hsp D). The gene discussed is TP53; the disease is Hyperkeratosis.