Further, we observed higher stage NB tumors showed significantly higher RAF1 and MAP2K2 expression levels (Kocak n = 649, RAF1 p = 8.9 × 10−4, MAP2K2 p = 2.33 × 10−18; SEQC n = 498, MAP2K2 p = 1.00 × 10−10; Versteeg n = 88, RAF1 p = 8.36 × 10−3, MAP2K2 p = 5.35 × 10−3; Figure 1D–F and Figure 2C,D), suggesting that RAF1 and MAP2K2 plays a significant role in NB progression. Here, RAF1 is linked to neuroblastoma.