Although cHL, Hodgkin and Reed/Sternberg cancer cells (HRS) have only a few B-cell line markers, immunoglobulin gene rearrangement studies have shown that in more than 98% of cases, these cells are derived from mature B-cells at the germline phase of differentiation and contain the clonal rearrangement of the immunoglobulin heavy-chain variable region (IGHV) gene and the somatic mutation of the V region genes [3]. This evidence concerns the gene SLC3A2 and classic Hodgkin lymphoma.