IL6 and colorectal carcinoma: In preclinical experiments, Rubinstein et al. found that FadA (a virulence factor of F. nucleatum) could promote expression of inflammatory genes (e.g., NF-κB, IL-6, IL-8, IL-18) through E-cadherin/β-catenin signaling, thus generating a proinflammatory microenvironment that is conducive for CRC progression [107].