In addition, high-frequency somatic mutations in chromatin-remodeling-related genes (for example, lysine (K)-specific methyltransferase 2C (KMT2C), lysine (K)-specific methyltransferase 2D (KMT2D), E1A binding protein p300 (EP300), and lysine (K)-specific demethylase 5A (KDM5A)), have also been documented in NPC [11]. Here, KMT2D is linked to nasopharyngeal carcinoma.