Frequent somatic mutations in genes involved in the PI3K/Akt/mTOR and MARK signaling pathways, such as phosphatase and tensin homolog (PTEN), PIK3CA, and fibroblast growth factor receptor 3 (FGFR3) have been found in NPC, and the most frequently mutated pathways are considered to be responsible for NPC progression [6,14]. This evidence concerns the gene PIK3CA and nasopharyngeal carcinoma.