Moreover, AITC induced G2/M phase cell cycle arrest in MCF-7, MDA-MB-231, and MDA-MB-468 human breast adenocarcinoma cells through the upregulation of p-ERK and p21/WAF1, which is a cyclin-dependent kinase inhibitor (CKI), and the downregulation of CDK1 and cyclin B proteins [26,52]. The gene discussed is CDKN1A; the disease is breast adenocarcinoma.