In fact, it has been reported that a derivative of ATRA inhibited TGF-β–induced liver fibrosis by suppressing the expression of the collagen 1A2 gene [8], and an isomer of ATRA, 9-Cis-retinoic acid, has been reported to attenuate the TGF-β–induced fibrotic changes within the cultured human mesangial cells [7]. Here, TGFB1 is linked to Hepatic fibrosis.