CXCL8 and neoplasm: Next, we analyzed in EAC data sets curated from The Cancer Genome Atlas the prognostic role of a panel of signatures (Supplemental Figure 7, A–E): the EAC signature, the neutrophil degranulation (signature derived from the EAC cluster), CXCL8/IL8, and neutrophil abundance, as estimated in tumor tissues by transcripts of the marker CD16 (13) (Fc gamma receptor IIIa and IIIb [FCGR3A/B]).