TP63 and SPT6 were suppressed in the squamous lining of the esophagus proximal to the BE segment (Figure 2F), and BE/EAC signatures and the neutrophil inflammatory milieu were similarly observed in the normal squamous lining of the esophagus proximal to BE and EAC lesions (Figure 6, A and B), suggesting that the histologically so-called normal esophageal lining is abnormal by all molecular (i.e., protein and gene expression) metrics among patients with BE or EAC. The gene discussed is TP63; the disease is Barrett esophagus.