Significant overlaps were seen between those 274 genes and the BE-associated SLC44A4 cluster (P = 1.59 × 10–10), but not the EAC-associated LILRB3- and IL10RA-clusters (Figure 4E), suggesting that the methylome in EAC is imprinted early during evolution through BE. Here, IL10RA is linked to Barrett esophagus.