IL1B and Barrett esophagus: Finally, because key features of the human disease is recapitulated in the IL-1β–tg murine model of BE-like tumorigenesis (30) (Supplemental Methods), where the glandular epithelia at the GEJ/cardia gave rise to BE, these glandular cells could serve as an alternative cell of origin of BE and EAC/GEJ-ACs.