IHC studies on FFPE biopsy specimens confirmed that, compared with specimens from participants without BE, both SPT6 and TP63 proteins were significantly suppressed in the esophageal squamous lining from patients whose disease had progressed to BE (P = 0.8 × 10–9 and 0.9 × 10–7, respectively; Figure 2G). Here, SUPT6H is linked to Barrett esophagus.