Induction of IL-8 and high neutrophils in BE tissues (32) and circulation (33) has been reported; however, in showing that this immune microenvironment is prominently induced in White individuals but not in AAs, which mirrors the approximately 4- to 5-fold higher risk of EACs in White individuals compared with AAs (34), our findings suggest that this inflammatory microenvironment is likely to be a driver event. This evidence concerns the gene CXCL8 and Barrett esophagus.