To facilitate these experiments, we crossed Ube3a+2 mice to Angelman syndrome (AS) model mice (AS/Ube3a+2), as the latter are devoid of UBE3A expression in mature neurons (38), effectively providing a blank backdrop against which Ube3aOE transgene expression can be plainly observed (Figure 2A). The gene discussed is UBE3A; the disease is Angelman syndrome.