CYP3A5 and chronic kidney disease: When we repeated the analysis for patients who were on dCCB but had no CKD history, 12.3% of CYP3A5 rs776746 TT homozygotes without prevalent CKD were diagnosed with incident CKD compared to 6.6% of heterozygotes and 6.8% homozygotes for CC (HR 2.09, 95% CI 1.29 to 3.37, P = .003; see Table S9 for details).