CYP3A5 and chronic kidney disease: Patients with CYP3A5 rs776746 TT (CYP3A5*3) genotype (0.47% of patients), a variant previously linked to kidney related outcomes26 had increased risk of CKD (HR 2.12: 95% CI 1.34 to 3.38, P = .002) compared to CC homozygotes (Figure 1 and Table 3).