Nanoparticles accumulating in RA joints via the ELVIS effect were picked up by activated macrophages and free TPT, which reduced pro-inflammatory cytokines such as TNF, IL-6, and IL-1.66 Nanocarriers could be used as endogenous vesicles that combine with biological cellular plasma membranes, reducing mononuclear phagocyte system elimination and boosting circulation time. The gene discussed is TNF; the disease is rheumatoid arthritis.