TP53 and cancer: Machine learning (ML) approaches have been used to investigate large and complex data sets, including the classification of cancer types, the determination of informative features in cancer diagnosis, and the analysis of TP53 mutations and their effects (Danziger et al., 2009; Chitrala et al., 2019; Grewal et al., 2019; Lim et al., 2019; Banerjee and Mitra, 2020; Yuan et al., 2020).