TP53 and neoplasm: The most frequently somatically mutated gene in human cancer is TP53 which encodes the p53 protein, signifying the importance of its wild-type function in tumor suppression (Levine and Oren, 2009; Kandoth et al., 2013; Duffy et al., 2014; Donehower et al., 2019; Thomas et al., 2022).