TLK2 and dermatofibrosarcoma protuberans: Table 4 shows the clinical traits of selected samples in the TCGA database. After removing the batch effect (Figure 4A), the diagnostic values of FAM118B (AUC: 0.837; Figure 4B) and TLK2 (AUC: 0.821; Figure 4C) were greater than 0.8. The diagnostic values of FAM20C (AUC: 0.741; Figure 4D) and ZNF286A (AUC: 0.706; Figure 4E) were weaker. By immunohistochemistry, TLK2 expression was positive while FAM118B was negative in DFSP tissues (Figure 4F). Thus, we hypothesized that TLK2 might be a biomarker for diagnosing DFSP based on our present samples.