Mounting evidence of presence of contiguous stretches of G’s are found not only in the telomeric region of eukaryotic chromosomes but also in other genomic locations (Sen and Gilbert 1988; Fry and Loeb 1994; SanthanaMariappan et al., 1996), promoter regions of several human proto-oncogenes including retinoblastoma gene susceptibility (Murchie and Lilley 1992) and c-myc (Simonsson et al., 1998), mutation and recombination hot spots (Simonsson 2001), and UTR’s (untranslated region) (Kumari et al., 2007). Here, MYC is linked to retinoblastoma.