Furthermore, several other studies reported in the literature depicted the role of Z-DNA-forming sequences in chromosomal breakage and translocation in genes such as human BCL-2 (Adachi and Tsujimoto 1990; Seite et al., 1993), c-myc (Rimokh et al., 1991; Wölfl et al., 1995), and the SCL (Aplan et al., 1992), cancer-causing genes. This evidence concerns the gene BCL2 and cancer.