SEC61A2, KHSRP, and SUGP2 were found to be significantly upregulated in FRDA, and KHSRP changed in the opposite direction in CT neurons vs. TT neurons, which might indicate that CT SIRT6 genotype results in a compensatory mechanism to “normalize” expression of this disrupted gene in FRDA. This evidence concerns the gene SUGP2 and Friedreich ataxia.