SIRT6 and Friedreich ataxia: We queried a publicly available transcriptomic data set (Nachun et al., 2018) generated from blood from people with FRDA for differential gene expression profiles between a larger number of patients with CT SIRT6 and TT SIRT6. Nine hundred and twenty genes were differentially expressed in the CT group compared to the TT group, and 832 genes were differentially expressed in the CT group compared to the TTmod group.