AKT1 and cancer: Additionally, we screened 146 pathways (p-values < 0.05) according to the results of KEGG analysis among these intersecting genes and found that the pathways in cancer, metabolic pathways, and PI3K/AKT signaling pathways were the top three highest-ranked significant pathways, with 54, 39, and 38 intersecting genes, respectively (Figure 3D).