The results of immunohistochemistry indicated that the protein expression of AR, BCL2L1, CREBBP, EGFR, MAPK8, and PTEN was downregulated (Supplementary Figures S3A–F), while NR3C1, HNF4A, and HDAC1 were upregulated in the HCC sample compared to normal liver tissues (Supplementary Figures S3J–L). This evidence concerns the gene MAPK8 and hepatocellular carcinoma.