ESR1 and hepatocellular carcinoma: Meanwhile, the prognosis of key genes in all TCGA HCC samples was also analyzed, and different from the previous analysis, the 5-year overall survival prognosis of HCC patients was better in the higher expression group of AR, CREBBP, EGFR, ESR1, HNF4A, MDM2, NR3C1, and PTEN (Supplementary Figures S2A–H), while the prognosis was better in the lower expression group of HDAC1 and SRC (Supplementary Figures S2K,L).