We next analyzed the expression of key genes in GSE62232 and TCGA databases, and the results showed that compared with normal liver tissues, the expression of AR, EGFR, ESR1, MAPK8, and PTEN were downregulated in HBV-related HCC tissues, and HDAC1 expression was upregulated. This evidence concerns the gene HDAC1 and hepatocellular carcinoma.