In the Oncomine database, we analyzed the expression of the key genes between normal liver tissues and HCC tissues, the results showed that among eight datasets, the expressions of BCL2L1, HNF4A, MDM2, NR3C1, and SRC were elevated in HCC tissues, while AR, CREBBP, EGFR, ESR1, MAPK8, and PTEN expressions were decreased (Figure 7D). This evidence concerns the gene ESR1 and hepatocellular carcinoma.