In the GSE62232 dataset, the results showed that compared to normal liver tissues, BCL2L1, CREBBP, HDAC1, MDM2, and NR3C1 genes were significantly upregulated in HBV-related HCC tissues, while AR, EGFR, ESR1, HNF4A, MAPK8, and PTEN genes were significantly downregulated (Figure 7A). This evidence concerns the gene ESR1 and hepatocellular carcinoma.