In the TCGA database, compared to normal liver tissues, HDAC1 and SRC were significantly upregulated in HBV-related HCC tissues, and AR, CREBBP, EGFR, ESR1, MAPK8, MDM2, NR3C1, and PTEN genes’ expression were significantly downregulated (Figure 7B), and the same results were observed between para-HCC and HCC tissues in all TCGA samples (Figure 7C). The gene discussed is ESR1; the disease is hepatocellular carcinoma.