JAK2 and myocardial ischemia: They further investigated the protective effects of 10-gingerol in mice, assuming that it confers protective effects against myocardial ischemia damage and the potential mechanisms of action by examining histopathological lesions, analyzing expression levels of cardiac enzymes, in vivo oxidative stress and apoptosis, and proteins involved in the Janus kinase 2 (JAK2)/signal transducer and activator of the transcription 3 (STAT3) signaling pathway.