By performing high-throughput sequencing, Sun et al. (Sun et al., 2021) discovered abnormal expression of serum exosomal circRNAs (exo-circRNAs) in patients with MM-related myocardial damage and abnormal expression of these circRNAs could interfere with MM-related myocardial damage by regulating miRNA and the TLR4 axis, providing a notion that exo-circRNAs might be a novel potential therapeutic target for this disease. Here, TLR4 is linked to Miyoshi myopathy.