Circ-MYBL2, a MM-associated circRNA, was reported to be dramatically decreased in MM tissue and serum samples; simultaneously, low serum circ-MYBL2 was closely associated with unfavorable outcome and had an excellent accuracy in diagnosing MM, which granted its potential as biomarker for MM patients (Yu et al., 2021). This evidence concerns the gene MYBL2 and Miyoshi myopathy.