BDNF and sexually transmitted disease: In the bilateral common carotid artery occlusion (BCCAO) surgery-induced VD rats, TMP therapy modulated the pro-and anti-apoptotic indicators, inhibited the elevated MCP-1 and homocysteine (Hcy) levels, and suppressed the lowered levels of brain-derived neurotrophic factor (BDNF) (Zhao et al., 2017).