APOE and atherosclerosis: Guo et al. found that 20(S)-Rg3 skewed macrophages to the M2 phenotype and decreased the expression of TNF-α, IL-6, IL-10, and transforming growth factor-β (TGF-β) to mitigate atherosclerosis in diabetic apoE−/− mice (Guo et al., 2018).