The common pathogenesis of insomnia may be caused by the enhanced activity of the hypothalamic-pituitary-adrenal (HPA) axis and the changes of cytokines such as interleukin (IL) and tumor necrosis factor (TNF), At present, the treatment of insomnia with anxiety in modern medicine mainly focuses on improving sleep quality and anti-anxiety treatment, and mostly uses sedative hypnosis and anti-anxiety drugs [48]. The gene discussed is TNF; the disease is Anxiety.