Based on the network analysis of active components of Salvia miltiorrhiza Bge. and ischemic stroke, it is concluded that Tanshinol B, Tanshinol A, Przewaquinone C, Tanshinone II A of Salvia miltiorrhiza Bge. have good binding effect on the key proteins of ischemic stroke, such as STAT3, MMP2, ESR1, TERT. The gene discussed is ESR1; the disease is ischemic stroke.