KEGG enrichment analysis involved 48 signaling pathways, and 15 KEGG pathways were screened by the number of genes more than 4, as shown in Figure S2D and Table S4, Metabolic pathways, Pathways in cancer, MicroRNAs in cancer, Proteoglycans in cancer, Steroid hormone biosynthesis, Insulin resistance, Alzheimer's disease, Nitrogen metabolism, Bile secretion, Serotonergic synapse, Natural killer cell-mediated cytotoxicity, and so on. The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.