Using PyMOL software, Discovery studio 4.5 client, and Autodock tools 1.5.6 software, the interaction between potential active compounds (Tanshinol A, Tanshinol B, Tanshinone II A and Przewaquinone C) and ischemic stroke related proteins (MMP2, STAT3, TERT, and ESR1) was studied (Figure 5). This evidence concerns the gene ESR1 and ischemic stroke.