Accordingly, among GBS patients, the role of some biomarkers such as tumor necrosis factor, hypocretin-1, neuron-specific enolase, myelin basic protein, neurofilaments, anti-ganglioside antibodies, neuron-specific enolase, neurofilaments, hypocretin-1, myelin basic protein, chemokines, and complements in disease prognosis and pathology has been established [11]. The gene discussed is ENO2; the disease is Guillain-Barre syndrome.