Endocytosis and subcellular localization occurred in vitro and metabolic distribution and accumulation occurred in vivo, and this process was observed through NIR fluorescence.42 To prevent the growth of human epidermal growth factor receptor 2 (HER2) expressing breast cancer cells, anti-HER-2-ICG-encapsulated PEG-coated PLGA NPs (HIPP NPs) were prepared for targeted phototherapy. The gene discussed is ERBB2; the disease is breast cancer.