The main advantages of ICG encapsulation were improvement of its stability and prevention of its rapid degradation in the tumor microenvironment.43 Lee and co-workers developed anti-HER2-ICG-DOX-encapsulated PEG–PLGA diblock (PEG-b-PLGA) copolymeric NPs (HIDPPNPs) for photochemotherapy and target-specific treatment of HER2-overexpressing breast cancer cells. This evidence concerns the gene ERBB2 and breast cancer.