CTX binds with high affinity and blocks the EGFR, which is overexpressed in several cancer cells.10 CTX-conjugated NPs have been widely used for the specific targeting of different kinds of cancer cells overexpressing EGFR, including lungs,11–13 gastric,14 colon,15–17 brain,18–20 and breast cancers.21–23. This evidence concerns the gene EGFR and breast cancer.